Two men were injured at about 2:30 a.m. Saturday morning after the car they were in left the road and struck the Santa Fe Trail Rail Road.
The accident happened at the Kerr Mansion and old U.S. Highway 271 intersection near Poteau.
The driver was thrown from the car and flown by medical helicopter to an Arkansas hospital.
The passenger also was injured and was taken by LeFlore County EMS to a Fort Smith, Ark., hospital.
Oklahoma Highway Patrol investigated the accident.