A head-on collision in Howe at about 10:30 a.m. Thursday morning has resulted in several people injured.
Witness reports say an SUV crossed the center line of U.S. Highway 59 striking a semi-tractor trailer head on.
Moments after the impact, witnesses say the semi exploded.
Emergency crews from Howe Fire and Police, LeFlore County Emergency Medical Services, Tulsa Life Flight and the Oklahoma Highway Patrol were on scene.
Initial reports say three people were injured in the accident. Two people were flown from the scene by medical helicopter.